Pooled Testing Method for Large-scale Identification of Asymptomatic Carriers of COVID-19
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Poold Diagnostics is developing a high-throughput diagnostic testing method for SARS-CoV-2 diagnostic screens. The companys pooled testing method allows diagnostic laboratories to increase their testing capacity by up to a factor of 20x using their existing diagnostic testing setup. The novel method identifies all positive subjects within a large set of samples using a single round of testing, thereby reducing test costs while increasing testing capacity.
The companys pooling-based efficient SARS-CoV-2 testing (P-BEST) method uses PCR together with a combinatorial pooling algorithm based on the mathematical theory of compressed sensing. The method, which was recently approved for clinical use by the Israeli Ministry of Health, has been used to screen over 5,000 subjects using only 700 pools and has correctly detected more than 60 positive carriers with no false negatives.
P-BEST was developed by a group of researchers from Ben-Gurion University of the Negev, the National Institute for Biotechnology in the Negev and The Open University of Israel. A study describing P-BEST was simultaneously published in August 2020 in the journal Science Advances and featured in a New York Times article. The method was also covered by Scientific American, Haaretz, the BBC, and other outlets.